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Sympathetic vs. Parasympathetic: What's the Difference?

Medicine & HealthSide-by-sideWritten comparisonAll comparisons

Read the comparison below, or explore it visually. Create a visual lesson comparing sympathetic and parasympathetic using available credits or plan allowance.

The sympathetic nervous system prepares the body for action, the fight-or-flight response, while the parasympathetic nervous system calms it and supports rest and digestion. Both are divisions of the autonomic nervous system, which runs organs without conscious control. Most organs receive nerves from both, and the balance between them sets heart rate, pupil size, digestion and many other functions moment to moment.

At a glance

SympatheticParasympathetic
Main roleFight or flight: mobilises energyRest and digest: conserves energy
Heart and lungsFaster heartbeat, wider airwaysSlower heartbeat, narrower airways
Digestion and eyesSlows digestion, dilates pupilsBoosts saliva and digestion, constricts pupils
Where nerves exitThoracic and upper lumbar spinal cordBrainstem (e.g. vagus nerve) and sacral cord
Main signal at organsMostly noradrenaline (norepinephrine)Acetylcholine

Which should you use?

Sympathetic

The sympathetic system takes over in sudden stress or exertion, such as swerving to avoid a scooter on a busy road, when the heart races, pupils widen and adrenaline is released.

Parasympathetic

The parasympathetic system dominates during calm, such as resting after a meal, when the heart slows, saliva and digestive juices flow and the intestines move food along.

Frequently asked questions

How is adrenaline linked to the sympathetic system?
Sympathetic nerves directly stimulate the inner part of the adrenal glands, the adrenal medulla, to release adrenaline into the blood. This hormone spreads the fight-or-flight effects around the body and makes them last longer than the nerve signals alone.
What is the vagus nerve?
The vagus nerve is the tenth cranial nerve and the main parasympathetic nerve. It runs from the brainstem down through the neck to the heart, lungs and most of the gut, slowing the heart and stimulating digestion.
Can you consciously control these systems?
Not directly, because both work automatically. Some actions influence them indirectly: slow, steady breathing tends to shift the balance towards parasympathetic activity and slow the heart. Persistent symptoms such as a racing heart or fainting should be checked by a doctor.