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How do red blood cells carry oxygen?
Quick answer
Red blood cells carry oxygen using haemoglobin, a protein with iron that binds oxygen in the lungs. Each cell contains about 270 million haemoglobin molecules. In tissues where oxygen is low, haemoglobin releases its oxygen, which then diffuses into cells for energy production.
Red blood cells carry oxygen by using haemoglobin, an iron-containing protein that binds oxygen in the lungs and releases it in tissues. Each red blood cell packs about 270 million haemoglobin molecules, giving blood its oxygen-carrying capacity.
Step by step
- Oxygen from inhaled air diffuses across the thin walls of the lungs' air sacs into the blood.
- Oxygen enters red blood cells and binds to iron atoms in haemoglobin molecules.
- Each haemoglobin molecule can bind four oxygen molecules, becoming fully saturated.
- Red blood cells travel through arteries and capillaries, delivering oxygen to tissues.
- In tissues with low oxygen, haemoglobin releases oxygen, which diffuses into cells.
- Red blood cells then return to the lungs via veins to pick up more oxygen.
Key things to understand
- Red blood cells are small, flexible discs packed with haemoglobin, the oxygen-binding protein.
- In the lungs, oxygen diffuses into red blood cells and binds to iron atoms in haemoglobin.
- Each haemoglobin molecule can carry four oxygen molecules, so one red blood cell carries over a billion oxygen molecules.
- In tissues with low oxygen, haemoglobin changes shape and releases oxygen for cells to use.
- Red blood cells lack a nucleus and most organelles, leaving more room for haemoglobin.
Labelled diagram
- Lungs
Oxygen enters air sacs and diffuses into the blood.
- Red blood cell
Haemoglobin binds oxygen, turning blood bright red.
- Arteries
Oxygen-rich blood is pumped from the heart to tissues.
- Capillaries
Oxygen leaves haemoglobin and enters tissue cells.
- Veins
Oxygen-poor blood returns to the lungs to reload.
Real-world examples
- During exercise, muscles use oxygen faster, so haemoglobin releases more oxygen to meet demand.
- At high altitudes like the Andes, low oxygen levels trigger the body to produce more red blood cells.
- In sickle cell disease, abnormal haemoglobin distorts red blood cells into crescent shapes, impairing oxygen delivery.
- Carbon monoxide poisoning blocks haemoglobin's oxygen-binding sites, which is why it is dangerous.
Common mistake
✗ Myth: Red blood cells carry oxygen by dissolving it in their fluid, like a liquid tank.
✓ Fact: Red blood cells carry oxygen mainly by chemical binding to haemoglobin, not by simple dissolution. Haemoglobin allows blood to carry about 70 times more oxygen than plasma alone could dissolve.
People also ask
What is haemoglobin and what does it do?
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Why do red blood cells have a biconcave shape?
Part of the guide: How Your Body Works →

