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Bacteria vs. Fungi: What's the Difference?

Medicine & HealthSide-by-sideWritten comparisonAll comparisons

Read the comparison below, or explore it visually. Create a visual lesson comparing bacteria and fungi using available credits or plan allowance.

Bacteria are single-celled prokaryotes with no nucleus, while fungi are eukaryotes whose cells have a nucleus and which range from single-celled yeasts to moulds and mushrooms built from thread-like hyphae. Fungal cells are also far larger, and their walls are made of chitin rather than the peptidoglycan of bacterial walls, which is why antibiotics and antifungal medicines work differently.

At a glance

BacteriaFungi
Cell typeProkaryotic: no nucleusEukaryotic: has a nucleus
Body formAlways single cells, sometimes in chainsSingle-celled yeasts or multicellular hyphae
Cell wallPeptidoglycanChitin
ReproductionBinary fission: one cell splits into twoSpores, budding or growth of hyphae
Everyday examplesLactobacillus in curd, Rhizobium in rootsBaker's yeast, bread mould, mushrooms

Which should you use?

Bacteria

Bacteria are at work when milk sets into curd overnight, as lactic acid bacteria turn milk sugar into acid, or when root-nodule bacteria fix nitrogen for pulses.

Fungi

Fungi are at work when yeast makes bread dough rise by releasing carbon dioxide, when black mould grows on stale bread, or when mushrooms decompose fallen leaves.

Frequently asked questions

Do antibiotics work against fungal infections?
No. Most antibiotics target bacterial features, such as peptidoglycan walls or bacterial ribosomes, that fungi do not have. Fungal infections like ringworm need antifungal medicines, which a doctor can recommend.
Are fungi plants?
No. Fungi form their own kingdom. They cannot photosynthesise and instead absorb food from their surroundings, and their walls contain chitin, not cellulose. Genetically they are more closely related to animals than to plants.
Which is bigger, a bacterium or a yeast cell?
A yeast cell is usually bigger. Typical bacteria are a few micrometres long, while yeast cells are often around 5 to 10 micrometres across and have far more internal structure.